Metabolic reprogramming is a hallmark of cancer.Somatic mutations in genes involved in oncogenic signaling pathways, including KRAS and TP53, rewire the metabolic machinery in cancer cells.We here set out to determine, at the single cell level, metabolic signatures in human colon cancer cells engineered to express combinations of activating KRAS ge
The availability of broad-band digital data allow "the analysis" of the seismic signal in the low-noise frequency band for structural and seismic source studies, We model complete seismograms -surface and body waves - for the December 13, 1 990, Eastern Sicily earthquake, recorded at regional distances on the MEDNET stations AQU, BNI and KEG, The i
This work has as goal to evaluate how the paper of Phillips, Lawrence and Hardy (2004) and their discourse analysis model has been appropriated in the Organizational Studies field.Using a bibliometric measure of quoters and the qualitative analysis of quotation context, this paper describes: (i) the way it was applied empirically in researches, (ii
White-nose syndrome (WNS) is an infectious disease that disrupts hibernation in bats, leading to premature exhaustion of fat stores.Though we know WNS does impact reproduction in hibernating female bats, we are unsure how these impacts are exacerbated by local climate factors.We compiled data from four southeastern U.S.states and used generalized l
Longitudinal bunch shaping is gaining increasing attention due to the large impact it has on modern accelerators.The existing methods for controlling the density profile fall into three categories: laser shaping, emittance exchange, or correlations between the energy and one of the other coordinates.These methods require either Books (i) dispersive